Repaglinide 1mg and Metformin Hydrochloride (Sustained-release) 500mg Tablets IP: Uses, Benefits, and Expert Advice
This combination medicine is used for the management of type 2 diabetes mellitus when diet and exercise alone do not provide adequate blood sugar control. It contains two active ingredients: Repaglinide (a meglitinide) and Metformin (a biguanide). The sustained-release formulation of Metformin allows for once-daily dosing in many cases, improving convenience and compliance.
Repaglinide + Metformin SR Uses
- Improves glycemic control in adults with type 2 diabetes.
- Helps reduce post-meal blood sugar spikes (Repaglinide works quickly after meals).
- Lowers overall blood glucose levels by decreasing insulin resistance and reducing glucose production in the liver (Metformin).
- Often used when metformin alone is not enough to control blood sugar.
How Repaglinide + Metformin SR Works
Repaglinide stimulates the pancreas to release more insulin shortly after meals, helping to control postprandial hyperglycemia. Metformin works by decreasing glucose production in the liver, improving insulin sensitivity, and reducing absorption of glucose from the intestines. The sustained-release version of metformin provides a more gradual release of the drug, leading to fewer gastrointestinal side effects compared to immediate-release metformin.
Common Side Effects of Repaglinide + Metformin SR
- Hypoglycemia (low blood sugar) – especially if meals are skipped, delayed, or if alcohol is consumed.
- Gastrointestinal issues: nausea, diarrhea, stomach upset, metallic taste (more common with metformin).
- Weight gain (possible with repaglinide).
- Headache, dizziness, or joint pain.
- Rare but serious: lactic acidosis (symptoms include muscle pain, trouble breathing, unusual sleepiness) – seek immediate medical help.
Expert Advice for Repaglinide + Metformin SR
- Take this medicine exactly as prescribed by your doctor, usually 15-30 minutes before meals (repaglinide is taken with meals). Do not skip meals after taking repaglinide.
- Monitor your blood sugar regularly as advised by your healthcare provider.
- Avoid alcohol while taking this medicine as it increases the risk of lactic acidosis and hypoglycemia.
- Inform your doctor if you have kidney or liver problems, heart failure, or if you are undergoing surgery or radiological procedures requiring contrast dye.
- Do not use this medicine if you have type 1 diabetes or diabetic ketoacidosis.
- Pregnant or breastfeeding women should consult a doctor before use.
Jan Aushadhi Price and Availability
Repaglinide 1mg + Metformin Hydrochloride SR 500mg tablets are available at Jan Aushadhi Kendras across India at an affordable price of ₹28.13 for a strip of 10 tablets. This is significantly cheaper than many branded alternatives, making diabetes management more accessible. Always check the packaging for the correct composition and expiry date. You can find this medicine at your nearest Jan Aushadhi Kendra or order online through authorized platforms.
Safety Note
This information is for educational purposes only and does not replace professional medical advice. Always consult your doctor or pharmacist before starting any new medication. Do not change your dose or stop taking this medicine without medical guidance. If you experience symptoms of low blood sugar (shakiness, sweating, confusion) or lactic acidosis (unexplained muscle pain, breathing difficulty), seek immediate medical attention.