Metformin Hydrochloride 500mg (SR) + Glimepiride 4mg Tablet: Uses, Benefits & Jan Aushadhi Price
This combination medicine contains two active ingredients: Metformin Hydrochloride (500mg sustained-release) and Glimepiride (4mg). It is commonly prescribed for managing type 2 diabetes mellitus when diet, exercise, and single-agent therapy do not provide adequate blood sugar control. The sustained-release formulation of Metformin allows for once-daily dosing in many cases, improving convenience and compliance.
Metformin + Glimepiride Uses
- Improves glycemic control in adults with type 2 diabetes
- Helps lower blood sugar levels when used alongside lifestyle modifications (diet and exercise)
- May be used as an add-on to metformin or sulfonylurea monotherapy
How Metformin + Glimepiride Works
Metformin belongs to the biguanide class and works primarily by decreasing glucose production in the liver and improving insulin sensitivity in muscle and fat tissues. It also reduces intestinal absorption of glucose. Glimepiride is a sulfonylurea that stimulates the pancreas to release more insulin. Together, they target different defects in type 2 diabetes: insulin resistance and insufficient insulin secretion.
Common Side Effects of Metformin + Glimepiride
- Gastrointestinal issues: nausea, vomiting, diarrhea, abdominal discomfort (more common with metformin)
- Hypoglycemia (low blood sugar): especially if meals are skipped, alcohol is consumed, or dose is too high
- Weight gain (more associated with glimepiride)
- Metallic taste (metformin)
- Rare but serious: lactic acidosis (metformin) – seek immediate medical help if symptoms like muscle pain, trouble breathing, or unusual drowsiness occur
Expert Advice for Metformin + Glimepiride
- Take this medicine exactly as prescribed, usually once or twice daily with meals to reduce stomach upset.
- Monitor blood sugar regularly, especially when starting treatment or adjusting dose.
- Do not skip meals, as this increases risk of hypoglycemia.
- Avoid alcohol while on this medication – it can increase risk of lactic acidosis and hypoglycemia.
- Inform your doctor if you have kidney or liver disease, heart failure, or are undergoing surgery or radiological procedures requiring contrast dye.
- Pregnant or breastfeeding women should consult a doctor before use.
Jan Aushadhi Price and Availability
Under the Pradhan Mantri Bhartiya Janaushadhi Pariyojana (PMBJP), this combination is available at a highly affordable price. The MRP for a strip of 10 tablets is ₹32.82, making it a cost-effective generic alternative to expensive branded versions. You can purchase it at any Jan Aushadhi Kendra across India. Always check the packaging for the correct composition and expiry date.
Safety Note
This information is for educational purposes only and does not replace professional medical advice. Always consult your doctor or pharmacist before starting any new medication. Verify the composition, strength, and suitability of this medicine with a healthcare professional. Do not self-treat or change your diabetes management plan without medical guidance.