Sitagliptin 100mg and Metformin 500mg Extended Release Tablets: Uses
This combination medicine is used to improve blood sugar control in adults with type 2 diabetes mellitus. It is typically prescribed when diet, exercise, and metformin alone do not provide adequate glycemic control. The extended-release formulation allows for once-daily dosing, which can improve convenience and adherence.
How Sitagliptin and Metformin Extended Release Works
Sitagliptin belongs to a class of drugs called DPP-4 inhibitors. It works by increasing the levels of incretin hormones, which stimulate insulin release from the pancreas in response to meals and reduce the amount of glucose produced by the liver. Metformin is a biguanide that works by decreasing glucose production in the liver, improving insulin sensitivity, and reducing glucose absorption from the intestines. The extended-release version releases metformin slowly over time, providing a more consistent effect and potentially fewer gastrointestinal side effects compared to immediate-release metformin.
Common Side Effects of Sitagliptin and Metformin Extended Release
- Nausea, vomiting, diarrhea, or stomach upset (especially when starting treatment)
- Headache
- Upper respiratory tract infection
- Nasal congestion or sore throat
- Joint pain
- Low blood sugar (hypoglycemia) when used with other diabetes medications like sulfonylureas or insulin
Serious side effects are rare but may include pancreatitis, severe allergic reactions, lactic acidosis (a rare but serious complication of metformin), and kidney problems. Seek immediate medical attention if you experience symptoms such as persistent severe abdominal pain, difficulty breathing, unusual muscle pain, or extreme weakness.
Expert Advice for Sitagliptin and Metformin Extended Release
- Take this medicine exactly as prescribed by your doctor, usually once daily with a meal to reduce stomach upset.
- Swallow the tablet whole; do not crush, chew, or split it, as this can affect the extended-release mechanism.
- Monitor your blood sugar regularly as advised by your healthcare provider.
- Inform your doctor about all other medications you are taking, especially other diabetes drugs, blood pressure medicines, or diuretics.
- Avoid alcohol while taking metformin, as it increases the risk of lactic acidosis.
- If you experience symptoms of low blood sugar (shakiness, sweating, confusion, rapid heartbeat), consume a fast-acting sugar source like glucose tablets or fruit juice.
- Do not use this medicine if you have severe kidney disease, metabolic acidosis, or a history of diabetic ketoacidosis.
- Pregnant or breastfeeding women should consult their doctor before using this medication.
Jan Aushadhi Price and Availability
Under the Pradhan Mantri Bhartiya Janaushadhi Pariyojana (PMBJP), Sitagliptin 100mg and Metformin 500mg Extended Release Tablets are available at a highly affordable price of ₹65.63 for a strip of 10 tablets. This makes it a cost-effective generic alternative to expensive branded versions. You can find this medicine at any Jan Aushadhi Kendra across India. Always verify the composition and strength with your doctor or pharmacist before purchasing.
Safety Note
This information is for educational purposes only and does not replace professional medical advice. Always consult your doctor or healthcare provider before starting any new medication, changing your dosage, or if you have any concerns about your treatment. Do not use this medicine without a valid prescription. In case of any adverse effects, seek medical help immediately.