Dapagliflozin 10mg, Vildagliptin 100mg (SR) and Metformin Hydrochloride 1000mg (SR) Tablets: Uses, How It Works, Side Effects, and Expert Advice
This combination medicine is used to improve blood sugar control in adults with type 2 diabetes mellitus. It contains three active ingredients that work together to lower blood glucose levels.
Uses of Dapagliflozin + Vildagliptin + Metformin
- Management of type 2 diabetes when diet and exercise alone do not provide adequate glycemic control.
- Often prescribed when patients are already on metformin and a DPP-4 inhibitor or SGLT2 inhibitor, or as a step-up therapy.
- May help reduce HbA1c levels and support weight management.
How This Combination Works
Each component targets different mechanisms in the body to lower blood sugar:
- Dapagliflozin (SGLT2 inhibitor): Blocks glucose reabsorption in the kidneys, causing excess sugar to be excreted in urine.
- Vildagliptin (DPP-4 inhibitor): Increases levels of incretin hormones, which stimulate insulin release and reduce glucagon secretion after meals.
- Metformin (biguanide): Decreases glucose production in the liver, improves insulin sensitivity, and reduces intestinal glucose absorption.
Together, they provide comprehensive blood sugar control with complementary actions.
Common Side Effects of Dapagliflozin + Vildagliptin + Metformin
- Urinary tract infections or genital yeast infections (due to dapagliflozin).
- Nausea, diarrhea, or stomach upset (especially when starting metformin).
- Headache, dizziness, or mild hypoglycemia (low blood sugar) when combined with other diabetes medications.
- Dehydration or low blood pressure (rare).
Most side effects are temporary. Consult your doctor if they persist or worsen.
Expert Advice for Dapagliflozin + Vildagliptin + Metformin
- Take this medicine exactly as prescribed, usually once or twice daily with meals to reduce stomach upset.
- Stay well hydrated to reduce the risk of urinary tract infections and dehydration.
- Monitor your blood sugar regularly, especially when starting or adjusting dose.
- Avoid alcohol as it can increase the risk of lactic acidosis (rare but serious with metformin).
- Inform your doctor if you have kidney or liver problems, heart failure, or are planning surgery.
- Do not stop or change your dose without consulting your healthcare provider.
Jan Aushadhi Price and Availability
Under the Pradhan Mantri Bhartiya Janaushadhi Pariyojana (PMBJP), this combination is available at a highly affordable price. The MRP for a strip of 15 tablets is ₹65.63, making it a cost-effective generic alternative to expensive branded versions. You can find it at any Jan Aushadhi Kendra across India. Always verify the composition and strength with your pharmacist.
Safety Note
This information is for educational purposes only and does not replace professional medical advice. Always consult your doctor or pharmacist before starting any new medicine. Do not use this medicine if you have type 1 diabetes, severe kidney disease, or are pregnant/breastfeeding without medical guidance. Keep out of reach of children.