Drotaverine Hydrochloride 80mg and Mefenamic Acid 250mg Tablets: Uses, How It Works, Side Effects, and Expert Advice
This combination medicine contains two active ingredients: Drotaverine Hydrochloride (an antispasmodic) and Mefenamic Acid (a non-steroidal anti-inflammatory drug or NSAID). It is commonly prescribed for the relief of abdominal pain and cramps associated with smooth muscle spasms, such as in conditions like irritable bowel syndrome (IBS), menstrual cramps (dysmenorrhea), and other gastrointestinal or gynecological spasms. Always consult your doctor before use.
Drotaverine + Mefenamic Acid Uses
- Relief of abdominal pain and cramps due to smooth muscle spasms (e.g., IBS, gastroenteritis)
- Management of menstrual pain (dysmenorrhea)
- Treatment of biliary colic (gallbladder pain) and renal colic (kidney stone pain) as part of a broader treatment plan
- Pain associated with gastrointestinal disorders like peptic ulcer disease (under medical supervision)
How Drotaverine + Mefenamic Acid Works
Drotaverine is a smooth muscle relaxant that works by inhibiting the enzyme phosphodiesterase-4 (PDE-4), leading to increased levels of cyclic AMP. This causes relaxation of smooth muscles in the gastrointestinal tract, uterus, and bile ducts, thereby relieving spasms and cramps. Mefenamic acid is an NSAID that reduces pain and inflammation by blocking the production of prostaglandins, chemicals that cause pain and swelling. Together, they provide effective relief from both the spasm and the pain.
Common Side Effects of Drotaverine + Mefenamic Acid
- Nausea, vomiting, or stomach upset
- Dizziness or headache
- Drowsiness or fatigue
- Dry mouth
- Constipation or diarrhea
- Allergic reactions (rash, itching) – seek medical help if severe
Most side effects are mild and temporary. If any side effect persists or worsens, consult your doctor.
Expert Advice for Drotaverine + Mefenamic Acid
- Take this medicine exactly as prescribed by your doctor. Do not exceed the recommended dose or duration.
- It is best taken with food or milk to reduce stomach upset.
- Avoid alcohol while taking this medicine as it may increase the risk of stomach bleeding or liver damage.
- Inform your doctor if you have a history of stomach ulcers, kidney disease, liver disease, heart problems, or asthma.
- Do not use this medicine during the last 3 months of pregnancy unless specifically advised by your doctor.
- If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue your regular schedule. Do not double the dose.
- Long-term use of NSAIDs like mefenamic acid may increase the risk of cardiovascular events or gastrointestinal bleeding. Use only for the shortest duration necessary.
Jan Aushadhi Price and Availability
This Jan Aushadhi medicine is available at a highly affordable price of ₹18.75 for a strip of 10 tablets. It is available at Jan Aushadhi Kendras across India. The generic version offers the same quality and effectiveness as branded alternatives at a fraction of the cost. Always check the packaging for the correct composition and expiry date.
Safety Note
This information is for educational purposes only and does not replace professional medical advice. Always consult a qualified healthcare provider before starting any new medication. Do not self-medicate or share your medicine with others. Keep out of reach of children.