Temozolomide Capsules IP 100mg Uses
Temozolomide is an oral chemotherapy medication used primarily to treat certain types of brain cancer, such as glioblastoma multiforme and anaplastic astrocytoma. It is also used in combination with radiation therapy for newly diagnosed glioblastoma and as maintenance therapy after radiation. This medicine belongs to a class of drugs called alkylating agents, which work by damaging the DNA of cancer cells, preventing them from dividing and growing.
How Temozolomide works
Temozolomide is a prodrug that is rapidly converted at physiological pH into the active compound MTIC (5-(3-methyltriazen-1-yl)imidazole-4-carboxamide). MTIC alkylates DNA, primarily at the O6 position of guanine, leading to DNA cross-linking and strand breaks. This triggers cell death, especially in rapidly dividing cancer cells. The drug is absorbed orally and crosses the blood-brain barrier effectively, making it particularly useful for brain tumors.
Common side effects of Temozolomide
- Nausea and vomiting (can be severe; antiemetics are often prescribed)
- Fatigue and weakness
- Decreased appetite
- Constipation or diarrhea
- Headache
- Low blood cell counts (neutropenia, thrombocytopenia, anemia) – increases risk of infection and bleeding
- Hair loss (alopecia)
- Skin rash
- Seizures (in patients with brain tumors)
Expert advice for Temozolomide
Temozolomide is a potent chemotherapy drug that requires careful medical supervision. Take it exactly as prescribed, usually once daily for 5 days in a 28-day cycle. It should be taken on an empty stomach, at least 1 hour before or 2 hours after a meal, with a full glass of water. Swallow capsules whole; do not open, crush, or chew them. If you vomit after taking a dose, do not take another dose; wait until the next scheduled dose. Your doctor will monitor your blood counts regularly to check for bone marrow suppression. Avoid live vaccines and contact with people who have infections. Use effective contraception during treatment and for some time after. Inform your doctor about all other medicines you take, as interactions can occur. Do not drive or operate machinery if you experience dizziness, confusion, or seizures.
Jan Aushadhi price and availability
Temozolomide Capsules IP 100mg is available under the Jan Aushadhi initiative at a significantly lower price compared to branded versions. The MRP for a bottle of 5 capsules is ₹1371.57, making it an affordable generic alternative for patients undergoing chemotherapy. You can purchase this medicine at any Jan Aushadhi Kendra across India. Always verify the batch and expiry date with the pharmacist. The generic version contains the same active ingredient and is equivalent in quality and efficacy to branded counterparts.
Safety note
This information is for educational purposes only and does not replace professional medical advice. Temozolomide should only be used under the supervision of a qualified oncologist. Do not self-medicate or change your dosage without consulting your doctor. If you experience severe side effects such as unusual bleeding, fever, signs of infection, or severe nausea/vomiting, seek medical attention immediately. Keep this medicine out of reach of children. Store at room temperature away from moisture and heat.