Dapagliflozin 10mg and Metformin Hydrochloride (Extended Release) 500mg Tablets: Uses, How It Works, Side Effects, and Expert Advice
This combination medicine is used to improve blood sugar control in adults with type 2 diabetes mellitus. It contains two active ingredients: Dapagliflozin and Metformin Hydrochloride (Extended Release).
Uses of Dapagliflozin + Metformin (ER) Tablets
- Management of type 2 diabetes when diet and exercise alone do not provide adequate glycemic control.
- Often prescribed when metformin alone is not sufficient, or when other medications are not suitable.
- May reduce the risk of cardiovascular death and hospitalization for heart failure in patients with type 2 diabetes and established cardiovascular disease or multiple risk factors.
How Dapagliflozin + Metformin (ER) Works
This combination works through two different mechanisms to lower blood sugar:
- Dapagliflozin belongs to a class of drugs called SGLT2 inhibitors. It works by blocking the reabsorption of glucose in the kidneys, causing excess sugar to be excreted in the urine.
- Metformin (extended release) works by decreasing glucose production in the liver, reducing absorption of glucose from the intestines, and improving insulin sensitivity.
The extended-release formulation of metformin allows for once-daily dosing and may cause fewer gastrointestinal side effects compared to immediate-release metformin.
Common Side Effects of Dapagliflozin + Metformin (ER)
- Urinary tract infections (UTIs) and genital yeast infections (due to dapagliflozin).
- Nausea, diarrhea, or stomach upset (especially when starting metformin).
- Dehydration or low blood pressure (due to increased urination).
- Hypoglycemia (low blood sugar) when used with other diabetes medications like insulin or sulfonylureas.
- Rare but serious: lactic acidosis (metformin), ketoacidosis (dapagliflozin), or kidney injury.
Expert Advice for Dapagliflozin + Metformin (ER)
- Take this medicine exactly as prescribed, usually once daily with a meal to reduce stomach upset.
- Stay well hydrated to reduce the risk of dehydration and kidney issues.
- Monitor your blood sugar regularly, especially when starting treatment or adjusting doses.
- Inform your doctor if you have a history of kidney disease, liver problems, or heart failure.
- Avoid alcohol while taking metformin to reduce the risk of lactic acidosis.
- Do not use if you have type 1 diabetes or diabetic ketoacidosis.
- If you experience symptoms of a urinary tract infection (painful urination, fever) or genital irritation, consult your doctor.
Jan Aushadhi Price and Availability
Under the Pradhan Mantri Bhartiya Janaushadhi Pariyojana (PMBJP), Dapagliflozin 10mg + Metformin Hydrochloride (ER) 500mg tablets are available at an affordable price of ₹47.82 for a strip of 10 tablets. This is significantly lower than many branded alternatives, making diabetes management more accessible. You can find this medicine at Jan Aushadhi Kendras across India. Always check the packaging for the Jan Aushadhi logo and verify the composition with your pharmacist.
Safety Note
This information is for educational purposes only and does not replace professional medical advice. Always consult your doctor or pharmacist before starting any new medication. Do not change your dose or stop taking this medicine without medical guidance. If you experience any severe side effects like difficulty breathing, swelling, or signs of lactic acidosis (muscle pain, weakness, unusual sleepiness), seek emergency medical help immediately.