Metformin HCl 500mg (SR) + Glimepiride 3mg Tablet: Uses, Benefits & Jan Aushadhi Price
This combination medicine contains two active ingredients: Metformin Hydrochloride (500mg in sustained-release form) and Glimepiride (3mg). It is commonly prescribed for managing type 2 diabetes mellitus when diet and exercise alone do not provide adequate blood sugar control. The sustained-release formulation of Metformin allows for once-daily dosing in many cases, improving convenience and compliance.
Metformin HCl + Glimepiride Tablet Uses
- Improves glycemic control in adults with type 2 diabetes
- Helps lower blood sugar levels when used alongside lifestyle modifications
- May be used as a second-line therapy when monotherapy with Metformin or Glimepiride is insufficient
How Metformin HCl + Glimepiride Tablet Works
Metformin works primarily by decreasing glucose production in the liver and improving insulin sensitivity in muscle and fat tissues. It also reduces glucose absorption from the intestines. Glimepiride, a sulfonylurea, stimulates the pancreas to release more insulin. Together, they target different defects in type 2 diabetes: insulin resistance (Metformin) and insufficient insulin secretion (Glimepiride). The sustained-release form of Metformin provides a gradual release of the drug, leading to more stable blood levels and fewer gastrointestinal side effects compared to immediate-release versions.
Common Side Effects of Metformin HCl + Glimepiride Tablet
- Hypoglycemia (low blood sugar) – especially if meals are skipped, alcohol is consumed, or exercise is increased
- Gastrointestinal issues: nausea, vomiting, diarrhea, abdominal discomfort (more common with Metformin)
- Metallic taste in the mouth
- Weight gain (more associated with Glimepiride)
- Allergic skin reactions (rare)
Expert Advice for Metformin HCl + Glimepiride Tablet
- Take this medicine exactly as prescribed by your doctor. Do not change the dose without consulting your healthcare provider.
- Monitor your blood sugar regularly, especially when starting treatment or adjusting doses.
- Do not skip meals, as this can increase the risk of hypoglycemia.
- Avoid alcohol consumption, as it can cause unpredictable blood sugar changes and increase the risk of lactic acidosis (rare but serious with Metformin).
- Inform your doctor if you have kidney, liver, or heart problems, or if you are planning surgery or any radiological procedure involving contrast dye.
- If you experience symptoms of hypoglycemia (sweating, shakiness, confusion, rapid heartbeat), consume a fast-acting sugar source like glucose tablets or fruit juice.
Jan Aushadhi Price and Availability
This medicine is available under the Pradhan Mantri Bhartiya Janaushadhi Pariyojana (PMBJP) at a highly affordable price. The MRP for a strip of 10 tablets is ₹28.13, making it a cost-effective generic alternative to many branded versions. You can find it at any Jan Aushadhi Kendra across India. Always check the packaging for the correct composition and expiry date. The Jan Aushadhi price for Metformin HCl 500mg SR + Glimepiride 3mg tablet is significantly lower than most branded alternatives, helping patients manage diabetes without financial burden.
Safety Note
This information is for educational purposes only and does not replace professional medical advice. Always consult your doctor or pharmacist before starting any new medication. Do not use this medicine if you are allergic to Metformin, Glimepiride, or any sulfonylurea. It is contraindicated in patients with severe kidney or liver disease, metabolic acidosis, or diabetic ketoacidosis. Pregnant or breastfeeding women should use this medicine only under medical supervision. Keep out of reach of children.