Dapagliflozin 10mg, Sitagliptin 100mg and Metformin Hydrochloride (Extended Release) 500mg Tablets: Uses
This combination medicine is used to improve blood sugar control in adults with type 2 diabetes mellitus. It is typically prescribed when diet, exercise, and other diabetes medications have not provided adequate glycemic control. The three active ingredients work together to lower blood glucose levels through different mechanisms.
How Dapagliflozin + Sitagliptin + Metformin works
This triple combination targets multiple pathways to control blood sugar:
- Metformin decreases glucose production in the liver and improves insulin sensitivity in muscles and fat tissues.
- Sitagliptin increases levels of incretin hormones, which stimulate insulin release after meals and reduce glucagon secretion.
- Dapagliflozin blocks glucose reabsorption in the kidneys, causing excess sugar to be excreted in urine.
Together, these actions help lower both fasting and post-meal blood glucose levels.
Common side effects of Dapagliflozin + Sitagliptin + Metformin
As with any medicine, side effects may occur. Common ones include:
- Nausea, diarrhea, or stomach upset (especially when starting metformin)
- Urinary tract infections or genital yeast infections (due to dapagliflozin)
- Headache, dizziness, or joint pain
- Low blood sugar (hypoglycemia) when used with other diabetes drugs like insulin or sulfonylureas
- Dehydration or electrolyte imbalance (rare)
Most side effects are mild and temporary. Contact your doctor if symptoms persist or worsen.
Expert advice for Dapagliflozin + Sitagliptin + Metformin
- Take this medicine exactly as prescribed, usually once daily with a meal to reduce stomach upset.
- Swallow the extended-release tablets whole; do not crush or chew them.
- Monitor your blood sugar regularly as advised by your doctor.
- Stay well hydrated, especially in hot weather or during exercise, as dapagliflozin can increase urine output and risk of dehydration.
- Avoid alcohol as it can increase the risk of lactic acidosis (a rare but serious side effect of metformin).
- Inform your doctor if you have kidney problems, liver disease, or a history of pancreatitis.
- Do not use this medicine if you have type 1 diabetes or diabetic ketoacidosis.
Jan Aushadhi price and availability
This medicine is available at Jan Aushadhi Kendras across India under the brand name Jan Aushadhi Dapagliflozin + Sitagliptin + Metformin ER. The MRP for a strip of 10 tablets is ₹67.50, making it an affordable generic alternative to expensive branded combinations. Always check the composition and strength on the packaging before purchase.
Safety note
This information is for educational purposes only and does not replace professional medical advice. Always consult your doctor or pharmacist before starting any new medication. Do not change your dose or stop taking this medicine without medical guidance. If you experience symptoms like severe abdominal pain, difficulty breathing, or signs of an allergic reaction (rash, swelling, itching), seek immediate medical help.