Dapagliflozin 5mg and Metformin Hydrochloride (Extended Release) 1000mg Tablets: Uses, Benefits, and Expert Advice
This combination medicine is widely prescribed for managing type 2 diabetes mellitus. It contains two active ingredients: Dapagliflozin (5mg) and Metformin Hydrochloride Extended Release (1000mg). Together, they help control blood sugar levels effectively. Below is a detailed guide for patients considering this Jan Aushadhi generic medicine.
Dapagliflozin + Metformin ER Uses
- Improves glycemic control in adults with type 2 diabetes when diet and exercise alone are insufficient.
- Often used when metformin alone does not provide adequate blood sugar control.
- May be used as an add-on to other diabetes medications like sulfonylureas or insulin.
- Helps reduce HbA1c levels and fasting/postprandial blood glucose.
How Dapagliflozin + Metformin ER Works
This combination works through two complementary mechanisms:
- Dapagliflozin is a sodium-glucose cotransporter-2 (SGLT2) inhibitor. It blocks glucose reabsorption in the kidneys, causing excess sugar to be excreted in urine. This lowers blood sugar levels and also promotes mild weight loss and blood pressure reduction.
- Metformin ER decreases glucose production in the liver, reduces intestinal absorption of glucose, and improves insulin sensitivity. The extended-release formulation provides smoother blood sugar control with fewer gastrointestinal side effects compared to immediate-release metformin.
Common Side Effects of Dapagliflozin + Metformin ER
- Urinary tract infections (UTIs) and genital yeast infections (due to increased sugar in urine).
- Nausea, diarrhea, or stomach upset (more common with metformin; ER version may reduce these).
- Dehydration or low blood pressure (especially in elderly or those on diuretics).
- Rare but serious: lactic acidosis (metformin-related, risk increases with kidney impairment).
- Rare: ketoacidosis (even with normal blood sugar) with dapagliflozin.
Expert Advice for Dapagliflozin + Metformin ER
- Take this medicine exactly as prescribed, usually once daily with a meal to reduce stomach upset.
- Swallow the tablet whole; do not crush, chew, or split it.
- Stay well hydrated to reduce the risk of dehydration and UTIs.
- Monitor your blood sugar regularly, especially when starting or adjusting dose.
- Inform your doctor if you have a history of kidney disease, liver problems, or recurrent UTIs.
- Avoid alcohol while taking metformin to reduce the risk of lactic acidosis.
- Do not use this medicine if you have type 1 diabetes or diabetic ketoacidosis.
- If you experience symptoms like unusual tiredness, muscle pain, stomach pain, or difficulty breathing, seek medical help immediately (possible lactic acidosis).
Jan Aushadhi Price and Availability
Under the Pradhan Mantri Bhartiya Janaushadhi Pariyojana (PMBJP), Dapagliflozin 5mg + Metformin Hydrochloride ER 1000mg tablets are available at an affordable price of ₹32.82 for 10 tablets (unit size: 10's). This makes it a cost-effective generic alternative to branded versions. You can find this medicine at any Jan Aushadhi Kendra across India. Always check the packaging for the Jan Aushadhi logo and verify the composition with your pharmacist.
Safety Note
This information is for educational purposes only and does not replace professional medical advice. Always consult your doctor or healthcare provider before starting any new medication. Do not switch from your current brand to this generic version without your doctor's approval, as dosage adjustments may be needed. Keep this medicine out of reach of children and store at room temperature (below 30°C).