Biphasic Isophane Insulin Injection IP (50:50) 40 IU per ml Uses
Biphasic Isophane Insulin Injection (50:50) is a pre-mixed insulin used to control blood sugar levels in people with diabetes mellitus. It contains 50% rapid-acting insulin (soluble insulin) and 50% intermediate-acting insulin (isophane insulin). This combination helps manage both post-meal glucose spikes and provides background insulin coverage throughout the day. It is commonly prescribed for type 2 diabetes when oral medications are not sufficient, and for some people with type 1 diabetes as part of their insulin regimen.
How Biphasic Isophane Insulin Injection works
This insulin works by replacing the body's natural insulin. The rapid-acting component starts working within 30 minutes, peaks around 2-4 hours, and lasts up to 8 hours. The intermediate-acting component begins working in about 2-4 hours, peaks at 4-12 hours, and can last up to 24 hours. Together, they help move glucose from the blood into cells, reducing blood sugar levels. The 50:50 ratio provides a balanced profile for patients who need both mealtime and basal insulin coverage.
Common side effects of Biphasic Isophane Insulin Injection
- Hypoglycemia (low blood sugar) – symptoms include sweating, dizziness, shakiness, hunger, confusion, and rapid heartbeat
- Injection site reactions – redness, swelling, itching, or pain at the injection site
- Weight gain
- Edema (fluid retention) – especially when starting insulin therapy
- Lipodystrophy – thickening or pitting of skin at injection sites if not rotated properly
Expert advice for Biphasic Isophane Insulin Injection
- Always check the insulin label before use – ensure it is the correct type and strength (40 IU per ml).
- Rotate injection sites (abdomen, thighs, upper arms) to prevent lipodystrophy.
- Do not mix this insulin with any other insulin in the same syringe unless advised by your doctor.
- Monitor blood sugar levels regularly as advised by your healthcare provider.
- Be aware of hypoglycemia symptoms and always carry a fast-acting sugar source (e.g., glucose tablets, candy, juice).
- Store unopened vials in a refrigerator (2°C–8°C). Do not freeze. Once opened, the vial can be kept at room temperature (below 30°C) for up to 28 days.
- Consult your doctor before adjusting doses or if you experience frequent hypoglycemia or hyperglycemia.
Jan Aushadhi price and availability
Biphasic Isophane Insulin Injection IP (50:50) 40 IU per ml is available at Jan Aushadhi Kendras across India at an affordable price of ₹88.00 for a 10 ml vial. This generic insulin offers significant cost savings compared to branded alternatives, making diabetes management more accessible. Always verify the composition and strength with your doctor or pharmacist before purchase.
Safety note
This information is for educational purposes only and does not replace professional medical advice. Always consult your doctor or diabetes educator before starting, stopping, or changing any insulin therapy. Insulin doses must be individualized based on your blood sugar levels, diet, activity, and overall health. Never share insulin pens or needles with others.