Methotrexate Tablets IP 7.5 mg Uses
Methotrexate is a disease-modifying antirheumatic drug (DMARD) and an antimetabolite used in various conditions. It is commonly prescribed for:
- Rheumatoid arthritis (moderate to severe active disease)
- Psoriatic arthritis
- Severe psoriasis (plaque psoriasis, psoriatic arthritis)
- Certain types of cancer (as part of chemotherapy protocols, e.g., acute lymphoblastic leukemia, non-Hodgkin lymphoma, osteosarcoma)
- Ectopic pregnancy (as a medical treatment)
Methotrexate is often used when other treatments have failed or are not tolerated. It helps reduce inflammation and slow disease progression in autoimmune conditions.
How Methotrexate Works
Methotrexate works by inhibiting dihydrofolate reductase (DHFR), an enzyme involved in the synthesis of folate. This leads to a decrease in the production of purines and pyrimidines, which are essential for DNA and RNA synthesis. In cancer cells, this inhibits cell division and growth. In autoimmune diseases, methotrexate reduces the activity of immune cells and decreases the production of inflammatory substances, thereby controlling inflammation and joint damage.
Common Side Effects of Methotrexate
Methotrexate can cause side effects, especially at higher doses. Common side effects include:
- Nausea, vomiting, loss of appetite
- Diarrhea or abdominal pain
- Mouth ulcers or soreness
- Fatigue, dizziness
- Hair loss (usually reversible)
- Elevated liver enzymes (monitored via blood tests)
- Increased risk of infections (due to lowered white blood cell count)
Serious side effects like liver damage, lung inflammation, or bone marrow suppression require immediate medical attention. Always report unusual symptoms to your doctor.
Expert Advice for Methotrexate
Methotrexate is a potent medication that requires careful monitoring. Here are key points:
- Take exactly as prescribed – usually once weekly for autoimmune conditions (not daily).
- Do not take folic acid supplements without consulting your doctor, as they may interfere with methotrexate. However, your doctor may prescribe folic acid to reduce side effects.
- Avoid alcohol completely – it increases the risk of liver toxicity.
- Regular blood tests (liver function, kidney function, complete blood count) are mandatory.
- Inform your doctor if you are pregnant, planning pregnancy, or breastfeeding – methotrexate is teratogenic and contraindicated in pregnancy.
- Use effective contraception during treatment and for at least 3 months after stopping.
- Do not take NSAIDs (like ibuprofen) without medical advice, as they may increase methotrexate toxicity.
Jan Aushadhi Price and Availability
Methotrexate Tablets IP 7.5 mg are available at Jan Aushadhi Kendras across India at an affordable price of ₹25.00 for a strip of 10 tablets. This generic version offers the same quality and efficacy as branded alternatives but at a fraction of the cost. Always check the packaging for the Jan Aushadhi logo and verify the composition with your pharmacist. The Jan Aushadhi price for methotrexate 7.5 mg makes it accessible for long-term treatment.
Safety Note
This information is for educational purposes only and does not replace professional medical advice. Methotrexate is a prescription-only medicine. Do not start, stop, or change the dose without consulting your doctor. Keep out of reach of children. Store at room temperature (below 25°C) away from moisture and light. If you experience severe side effects like difficulty breathing, jaundice, or unusual bleeding, seek immediate medical help.