Azathioprine Tablets IP 50 mg Uses
Azathioprine is an immunosuppressant medicine used to prevent organ rejection after kidney transplantation. It is also prescribed for severe rheumatoid arthritis and certain autoimmune diseases like lupus nephritis, inflammatory bowel disease (Crohn's disease, ulcerative colitis), and autoimmune hepatitis. It works by reducing the activity of the body's immune system.
How Azathioprine works
Azathioprine is a purine analog that interferes with the synthesis of DNA and RNA in rapidly dividing cells, particularly lymphocytes (a type of white blood cell). By suppressing the proliferation of these immune cells, it dampens the immune response, thereby preventing the body from attacking a transplanted organ or reducing inflammation in autoimmune conditions.
Common side effects of Azathioprine
- Nausea, vomiting, or loss of appetite
- Diarrhea
- Increased risk of infections (due to lowered immunity)
- Bone marrow suppression (low white blood cells, red blood cells, platelets) – may cause fatigue, easy bruising, or fever
- Liver enzyme elevation
- Hair loss (usually temporary)
- Skin rash
Expert advice for Azathioprine
- Take azathioprine exactly as prescribed, usually once or twice daily with food to reduce stomach upset.
- Regular blood tests (complete blood count, liver function) are essential to monitor for bone marrow suppression and liver toxicity.
- Avoid live vaccines while on azathioprine; consult your doctor before any vaccination.
- Inform your doctor if you have any infection, fever, sore throat, or unusual bleeding/bruising.
- Do not stop or change the dose without medical advice, as it may lead to transplant rejection or disease flare.
- Use effective contraception during treatment and for a period after stopping, as azathioprine can harm an unborn baby.
Jan Aushadhi price and availability
Azathioprine Tablets IP 50 mg are available at Jan Aushadhi Kendras under the Pradhan Mantri Bhartiya Janaushadhi Pariyojana (PMBJP). The MRP for a strip of 10 tablets is ₹45.00, making it an affordable generic alternative to expensive branded versions. Always verify the composition and strength with your doctor or pharmacist before use.
Safety note
This information is for educational purposes only and does not replace professional medical advice. Azathioprine is a potent immunosuppressant with significant side effects. Do not use it without a valid prescription and regular medical supervision. Consult your doctor for personalized dosage, duration, and monitoring.