Liposomal Amphotericin B Injection 50 mg per Vial: Uses
Liposomal Amphotericin B is an antifungal medicine used to treat serious, life-threatening fungal infections such as:
- Invasive aspergillosis
- Cryptococcal meningitis in HIV patients
- Visceral leishmaniasis (kala-azar)
- Systemic candidiasis in immunocompromised patients
- Fungal infections in patients who cannot tolerate conventional amphotericin B due to kidney problems
It is also used empirically in patients with fever and low white blood cell counts (neutropenia) when a fungal infection is suspected.
How Liposomal Amphotericin B works
Liposomal Amphotericin B contains the active ingredient amphotericin B encapsulated in liposomes (tiny fat bubbles). This formulation reduces toxicity while maintaining antifungal activity. The medicine binds to ergosterol, a key component of fungal cell membranes, creating pores that cause leakage of essential ions and cell death. The liposomal delivery helps the drug target fungal cells more selectively and reduces damage to human cells, especially kidney cells.
Common side effects of Liposomal Amphotericin B
- Infusion-related reactions: fever, chills, rigors, headache, nausea, vomiting (can be reduced by premedication)
- Low potassium levels (hypokalemia)
- Low magnesium levels (hypomagnesemia)
- Increased creatinine (kidney function changes) – less common than with conventional amphotericin B
- Anemia (decreased red blood cells)
- Rash or itching
Expert advice for Liposomal Amphotericin B
- This medicine is given as an intravenous (IV) infusion in a hospital setting under medical supervision.
- Your doctor will monitor your kidney function, electrolytes (potassium, magnesium), and blood counts regularly during treatment.
- Premedication with antihistamines, antipyretics, or corticosteroids may be given to reduce infusion reactions.
- Inform your doctor if you have any kidney disease, heart problems, or are taking other medications that affect kidneys.
- Do not stop treatment abruptly; complete the full course as prescribed.
- Liposomal Amphotericin B is generally better tolerated than conventional amphotericin B, but still requires careful monitoring.
Jan Aushadhi price and availability
Liposomal Amphotericin B Injection 50 mg per vial is available at Jan Aushadhi Kendras under the Pradhan Mantri Bhartiya Janaushadhi Pariyojana (PMBJP). The Jan Aushadhi price is ₹2700 per vial (20 ml), which is significantly lower than branded alternatives. This makes life-saving antifungal therapy more affordable for patients. Availability may vary by location; check with your nearest Jan Aushadhi Kendra or visit the official PMBJP website for stock information.
Safety note
This information is for educational purposes only and does not replace professional medical advice. Liposomal Amphotericin B is a prescription-only medicine and must be used under the supervision of a qualified healthcare provider. Always verify the composition, strength, and suitability of any medicine with your doctor or pharmacist. Do not self-administer or share this medicine with others.